Obesity is regarded as an increasingly prevalent health problem accompanied by adverse health effects. Despite the vast research assessing nutrition knowledge of patients regarding several health conditions, existing research assessing the nutrition knowledge of post-bariatric surgery patients is limited, although this category of patients is very susceptible to malnutrition. The aim of this study was to assess the patients' general nutrition knowledge and knowledge specific to the dietary protocol post-surgery. This study assessed the medical and nutritional complications associated with surgery. Results showed that the questions assessing nutrition knowledge of the dietary protocol showed that 66.2% of the participants had average knowledge and most patients did not know what dumping syndrome. On the other hand, majority followed up with a dietitian, although only 30.1% showed compliance to the dietitian's instructions. This was strongly related to majority of patients (71.2%) finding the information conveyed as unclear. As for overall quality of life, most of the patients had better quality of life. Future research on this category of patients is definitely needed.
The objective of the research is to develop an integrated social media healthcare model to support the effective adoption of the social media by the healthcare professionals in practice; Moreover, it highlights the multiple factors that relate to the practitioner's behavioral usage of the platforms. The study will draw on the Integrated Behavioral Model as a theoretical background; Moreover, we will identify the influence of the habit and the environmental factors that facilitate or inhibit the successful integration of the behavior. The research will use mixed methods for data collection and analysis. The qualitative phase will explore the salient beliefs of the social media usage. The final stage will associate the variables quantitatively with the effective integration of the social media. The results and analysis of our research aim to inform the healthcare professionals about the best integration of the social media in practice for sustainable performance and health outcomes.
Life course epidemiology dictates that health outcomes can be attributed to habits of the mother even before conception. We aim to investigate the issues which influence fetal and maternal health. Emirati women were recruited between May and September 2017 at a private hospital in Al Ain. We collected information on demographic factors, previous pregnancies, and medication use among others through a self-administered questionnaire. Their medical records were also extracted. 169 women were approached, and 100 (59%) were recruited. Participants were mostly multigravida (56%) with an average of 3 children. Majority of the population was overweight or obese with BMI above 27. 4. 23% suffered from gestational diabetes. There are some challenges in recruiting the local pregnant population and prevailing issues in the community such as higher BMI and gestational diabetes. The overall cohort which aims to recruit 10 000 women will shed light into risk factors that attribute to poor health outcomes.
The study aimed at investigating the perception on the impact of homecare accreditation on patients safety and quality of care which relate to infection rate, risk of fall, and medical documentation. The study will be a quantitative research method using a cross-sectional descriptive analysis and time series regression analysis which will test the theory that healthcare accreditation has a positive influence on patients safety and quality of care. The study is to be conducted in homecare facilities in the United Arab Emirates through sampling method for a group of 200 respondents to evaluate the impact of homecare accreditation. Questionnaires will be administered, and the response rate will be assessed using a Likert scale for measurement. The study results should assist in encouraging private and public homecare facilities to be accredited by international or national groups to achieve an optimum level of patients care at homecare setting.
Honey and its potential benefits are deeply engrained in our culture and religion. Manuka honey (MH), produced in New Zealand by bees that pollinate the Manuka bush, is one of the best studied honeys in the world. The medicinal properties of MH have been extensively studied, particularly in terms of its wound healing and antimicrobial activities. However, until recently, the scientific basis of Honey's effect on health and disease was largely unknown. Over the past eight years, we demonstrated the potential of using MH to prevent and treat cancer. So far, we have highlighted the beneficial effect of MH on breast, colon and skin cancers. We recently identified the precise molecular target of MH on human breast cancer cells. At present, we are continuing our work to characterize the precise mechanism(s) by which MH acts against different functional properties of cancer cells and map the potential active component responsible for each of its actions.
The stem cells are becoming a powerful tool in different fields of biomedical research such as disease modeling, drug testing and tissue engineering for regenerative medicine. Because little is known about the characteristic features and functional properties of stem cells, isolating stem cells from organs and maintaining them to differentiate are challenging tasks. In this study, we have used two protocols of three-dimensional (3D) culture to reveal some properties of gastric stem cells. In the first model, an immortalized epithelial cell line with molecular and morphological features representative of the mouse gastric stem (mGS) cells has been used to develop 3D culture models known as spheroids. In the second 3D spheroids model, stomach glands isolated from neonatal mice were used. Spheroids are characterized by using RT-qPCR, electron microscopy and immunohistochemistry to detect cellular phenotypes and any evidences of differentiation. These spheroids will remain as a valuable tool to develop models for various diseases such as Helicobacter Pylori and viral infections. In conclusion, this study will provide some data for the better understanding of the biological features of gastric stem cells in health and disease.
Cervical cancer is a global health problem that affect many women. Little is known about the cellular origin and the epithelial lining of the uterine cervix. The aim of this study is to characterize the cells lining the uterine cervix in mice using lectins histochemistry, immunohistochemistry and electron microscopy methods. To identify dividing cells and define their dynamics, the bromodeoxyuridine (BrdU) labeling technique is used. We noted that Griffonia simplicifolia agglutinin-1(GS-1) lectin was specific for the stratified epithelium in ectocervix region. Single injection studies of BrdU positive cells were scattered along the simple columnar glandular epithelium of endocervix and in the basal layer of the stratified squamous epithelium of ectocervix.
The gastric stem cell proliferates and migrate bidirectionally to maintain the glandular homeostasis. Abnormality in this dynamic process leads to gastric diseases. Vitamin A influences the cell proliferation and differentiation of various epithelial tissues. This study aims to analyse the role of vitamin A in the development of gastric glands. Vitamin A free diet was given to establish vitamin A deficient (VAD) model. A reduction in cell proliferation and an increase in the census of surface mucus cells was observed in the vitamin A deficient gastric glands. The findings from this study suggested that the vitamin A is an important factor that controls cell proliferation and differentiation in the mouse stomach.
Src homology region 2 domain-containing protein tyrosine phosphatase2 (SHP2) is ubiquitously overexpressed in lung, breast, leukemia and cervical tumors. The phosphorylation of SHP2 activates RAS-MAPK, mTOR, and PI3K-AKT signaling pathways which involved in cell proliferation, invasion and metastasis. Therefore, targeting SHP2 pathway becomes a novel approach in therapeutic intervention to inhibit tumor progression and metastasis. In the present study, we have investigated the SHP2 inhibitory effects of two newly synthesized 5-aminosalicylate-4- thiazolinone derivatives (HH3 & HH13) in HeLa, MCF-7 and MDA-MB-231 cells. In-silico molecular docking studies showed preferential affinity of HH compounds towards the catalytic site of SHP2 enzyme. An enzymatic SHP2 allosteric inhibitory assay showed HH compound's potential to suppress SHP2 activity. A confirmatory western-blot result further demonstrate the inhibitory effects for SHP2 expression in HeLa cells as similar to a positive control (NSC 87877). Furthermore, our data showed that these compounds suppresses RAS/MAPK pathway and regulate STAT3 and JNK expression in HeLa cells and thereby inhibit tumor cell proliferation and migration. Overall, our novel HH compounds showed remarkable potential to inhibit protein tyrosine phosphatase SHP2 and can lead to the development of a successful anti-SHP2 drugs.
Frequency modulated continuous wave radar is used to measure the target's distance and velocity. This paper elaborates the analysis of stationary target by using the FMCW radar. The radar was tested to detect a stationary target at considerable distances. Experimental results are compared with theoretical values to demonstrate the capability of the radar to detect targets.
