In view of understanding inheritance and enhancing personalized and predictive medicine, genetic data attracts attention. Typically genetic data is high dimensional and not simple to get hold of. In this paper, we present a pipeline that connects data simulation, dimensionality reduction, and visualization with Principle Component Analysis (PCA), for better inference of genetic data.
Acrylamide, also called 2-propenamide or AA, is an unsaturated amide with a chemical composition of C3H5NO (MW = 71.08 g/mol) was classified as "probably carcinogenic to humans" by the International Agency for Research on Cancer (IARC). It is formed in starchy food after frying, baking, or grilling. The literature stated that there are so many approaches in reducing acrylamide by changing the cooking conditions, adding specific ingredients or removing others. The practice of experimenting the effect of lactic acid bacteria removal on toxins showed positive results and further studies are needed to use lactic acid bacteria industrially. The aim of this research is to test lactic acid bacteria ability in removing acrylamide in vitro in order to provide more options for manufacturers to enhance food safety levels without jeopardizing the quality of their food products.
Date seeds contain several antioxidants and phenolic compounds that can provide functional characteristics to foods. These compounds can function as a prebiotic in yoghurt. This study involves ultrasonic extraction of aqueous soluble compounds from date seed powder and examining the effect of extract (D.S.E) on the functional characteristics of low-fat and full-fat yoghurt from cow milk. The yoghurt samples(with/without) were studied for functional properties such as viscosity, Water Holding capacity (W.H.C), Syneresis along with chemical properties such as Titratable Acid (T.A) and pH at 0, 3, 5 and 10 days of storage. D.S.E of 2% was added to yoghurt samples of low-fat and full-fat namely LFE and FFE, respectively. The study showed that viscosity improved during storage. No significant differences were observed for syneresis and W.H.C.
Probiotic bacteria can provide health benefits when delivered in functional foods. Promising 6 probiotic strains isolated previously from salted anchovy fish, E. faecium MF047470, MF047495, MF047509, and KY962874, E. faecalis KY962905, and E. durans KY962882, were used to prepare functional fermented fish sausages. Probiotic strains were then evaluated for cytotoxicity activity against two cancer cell-lines, antidiabetic activity as determined by α-amylase and α-glucosidase inhibition. The α-amylase and α-glucosidase inhibition from fish sausages fermented by 6 isolates of Enterococcus spp. ranged from 29.2 to 68.7% and 23.9 to 41.4%, respectively, during 21 days of storage. The cytotoxicity activities against Caco2 and MCF-7 cells of fish sausages fermented with Enterococcus spp. ranged from 18.0 to 24% and 13.9 to 27.9%, respectively. Fish sausages fermented by potential probiotic isolates of Enterococcus spp. from dried fish had valuable health-promoting benefits compared with non-fermented control sausages.
Wound healing is important for survival of organism. Many local and systemic factors effect on speed of wound healing. In the oral cavity, mucosal wounds healed faster than skin wound because of presence of saliva which contain different proteins, enzymes and elements with different regenerative functions. The aim of this study is to investigate the role of salivary histatin-1 in enhancing oral wound healing in-vitro. Human periodontal ligament fibroblast cell lines were grown in 24 well plates till confluence, then subjected to scratch assay that resemble oral wound. Complete medium added to control wells and complete medium with histatin-1 (10 ng) added in study wells. Cell migration assay was observed using an inverted microscope at 6, 12 and 24 hr. and gene expression for MMP-8 was quantified. Results showed that salivary histatin-1 enhances cell proliferation, migration and increase MMP-8 gene expression, enhancing the in-vitro wound healing process.
Objective: This study aimed to assess the fatigue resistance after thermo-mechanical cycling in a chewing simulator machine, and the fracture resistance by recording the load to failure in a universal testing machine, of two thicknesses of ultra-thin porcelain laminate veneers (UTLV) (0.2 and 0.4 mm), using two different cementation techniques (light cure resin cement and preheated resin composite).
Objective. The aim of the study was to assess the prevalence and characteristics of the referred pain associated with TMD diagnosed according to the DC/TMD. Study design: A total of 50 patients were enrolled in this study and they were examined according to DC/TMD criteria (Axis I and Axis II). MRI and CBCT were used for diagnosis of specific TMD classes. Results: The highest incidence of referred pain was recorded in patients diagnosed with anterior disc displacement with reduction (16%). A positive Pearson product-moment correlation was found between the Axis I DC/TMD diagnosis, pain level, mouth opening, duration of symptom and referred pain. A negative Pearson product-moment correlation was found between referred pain and the disability score. Conclusion: The results of this study facilitate the diagnosis process of TMD by evaluating the prevalence and characteristics of referred pain which is the main factor that complicates the diagnosis of TMD.
A high resolution (~30m) 2D Hydrodynamic model was run to investigate the impact of a 0.5m sea level rise on the Abu Dhabi coastline. The model incorporates the combined effects of sea level rise tidal forcing and storm surge (using the DELFT3D model), wind and wave forcings encountered during a typical Shamal wind event (using the SWAN model) in addition to wave run-up calculations. The model results showed that several islands and coastal areas containing important highway links would be inundated during such an event. While the northern coastlines of Saadiyat Island, Lulu Island are mainly affected by storm run-up and waves, some inland inlets such as the head of the South Mussafah Channel may also be affected by the tidal elevations experienced by sea level rise.
This research is focusing on the behavior of a tapered concrete filled steel tube column (CFST) connected to encased composite column (SRC) under axial compression and uni-axial bending. The purpose of having two different sections along the column height is to enhance flexure resistance of the column at the top edge by introducing CFST element, while the lower part is modeled as SRC element which is subjected mainly to axial compression with significant reduction in bending moments. The behavior of the composite column has been studied using different cylinder concrete strength ranging from C40MPa to C70MPa. Two steel grades of S275MPa and S355MPa has been adopted in this research. The research illustrates Load Path and Stress / Strain distribution under Axial compression and Uni-axial bending. Furthermore, it displays the composite column capacity along its height by adopting 3D-finite element fiber model and simplified approach by Eurocode and American Standards.
The efficiency of carbon fiber reinforced polymer (CFRP) strips to enhance reinforced concrete (RC) columns were investigated. Concentric and eccentric loads were imposed on the columns, leading to uniaxial and biaxial bending. 27 RC column specimens that had varying strengthening ratios have been utilized. The samples were categorized into 3 groups: axial, uniaxial and biaxial. In every category it was divided into several sub-groups accompanied with a control specimen that was not strengthened. The strengthened specimens showed a significant increase in the load-carrying capacity and ductility over the control specimens. The increase in the load-carrying capacity for confined columns strengthened with strips in axial, uniaxial and biaxial bending ranged from 36 to 49%, 48 to 95% and 76 to 128%, respectively.
